Blood and CSF Biomarker Dynamics in Multiple Sclerosis: Implications for Data Interpretation

@inproceedings{Eikelenboom2011BloodAC,
  title={Blood and CSF Biomarker Dynamics in Multiple Sclerosis: Implications for Data Interpretation},
  author={M. Judith Eikelenboom and Bernard M. J. Uitdehaag and Axel Petzold},
  booktitle={Multiple sclerosis international},
  year={2011}
}
Background. Disability in multiple sclerosis (MS) is related to neuroaxonal degeneration. A reliable blood biomarker for neuroaxonal degeneration is needed. Objectives. To explore the relationship between cerebrospinal fluid (CSF) and serum concentrations of a protein biomarker for neuroaxonal degeneration, the neurofilaments heavy chain (NfH). Methods. An exploratory cross-sectional (n = 51) and longitudinal (n = 34) study on cerebrospinal fluid (CSF) and serum NfH phosphoform levels in… CONTINUE READING

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