Blood Viscosity: Influence of Erythrocyte Deformation

@article{Chien1967BloodVI,
  title={Blood Viscosity: Influence of Erythrocyte Deformation},
  author={Shu Chien and Shunichi Usami and Robert J. Dellenback and Magnus I. Gregersen},
  journal={Science},
  year={1967},
  volume={157},
  pages={827 - 829}
}
Suspensions of canine and human erythocytes hardened with acetaldehyde differ from the suspensions of normal erythrocytes with respect to their rheological behavior. Normal erythrocytes can be packed by centrifugation so that the sediment volume is nearly 100 percent cells, but the hardened erythrocytes (RBC's) can be packed only to approximately 60 percent cells. At the same cell percentage the viscosity of the hardened RBC suspension is higher than that of the suspension of normal erythocytes… 
Red Blood Cell Deformability and its Hemorheological Consideration
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It was found that RBC deformability played an important role in reducing viscosity at low shear rates as well as highShear rates, which can be used in early diagnosis of the cardiovascular diseases.
Shear Dependence of Effective Cell Volume as a Determinant of Blood Viscosity
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The viscosity of suspensions of human erythrocytes was measured over a wide range of shear rates, and the macrorheological data were correlated with the micror heological behavior of ery throatcytes and rigid particles.
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The data suggest that fibrinogen causes an increase in blood viscosity and a departure from Newtonian behavior by interacting with erythrocytes to form cell aggregates which can be dispersed by shear stress.
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Experimental examples with concentrated RBC suspensions are presented and a discussion on the importance of the superposition of a constant shear flow to the pure oscillation, which is usually used to extract the viscoelastic properties of a complex fluid is presented.
Influence of Deformability of Human Red Cells upon Blood Viscosity
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The physiological deformability is of critical importance to blood flow at high rates of shear through a fluid transition of the erythrocyte caused by a rotation of the membrane with and around the cell contents, the prime cause of the progressive reduction in viscosity with increasing shear.
Erythrocyte Flexibility and Whole-blood Viscosity
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It has become accepted that the flexibility of red blood cells and the plasma viscosity are the main factors which determine the viscosities of blood at high shear rates, though quantitative evidence for this hypothesis is lacking in the range of viscosITY between these two extremes.
Rheology of blood: effect of dilution with various dextrans.
Abnormal rheology of oxygenated blood in sickle cell anemia.
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A role is assigned to the abnormal rheology of Hb SS erythrocytes in the pathogenesis of sickle cell anemia, even under conditions of complete oxygenation.
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References

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Blood Viscosity: Influence of Erythrocyte Aggregation
TLDR
The data suggest that fibrinogen causes an increase in blood viscosity and a departure from Newtonian behavior by interacting with erythrocytes to form cell aggregates which can be dispersed by shear stress.
Comparison of Viscometric Behaviour of Suspensions of Polystyrene Latex and Human Blood Cells
TLDR
To examine the influence of cell shape and deformability on blood viscosity, the viscosities of suspensions of red blood cells and suspensions of rigid, spherical latex particles with diameters comparable to the major diameters of red cells in human blood are compared.
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TLDR
Using a technique of treating the data to obtain rate-of-shear versus shearing-stress curves without prior assumption of a flow equation showed that whole blood over a wide range of shear stresses and a twofold range of capillary radii did not show any dependence of the viscosity on the capillaries employed.
Flow Characteristics of Human Erythrocytes through Polycarbonate Sieves
TLDR
The observed critical pore diameter for 100 percent cell transmission agrees with theoretical calculation based on the assumption that the RBC membrane is deformable but nonextensible and the importance of cell deformation in the passage of RBC through small pores is shown.
Red Blood Cells: Change in Shape in Capillaries
Evidence obtained from high-speed cinephotography of the microcirculation in the mesentery of the dog shows that the shape of the red blood cell is changed during its flow through capillaries from a
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TLDR
It is deduced from the equivalent binding of CNS, I, Cl, and F, the pH mobility relationships, and the conformation of the ionic strength data in the stable state to a Langmuir adsorption isotherm, that the membrane of the human erythrocyte behaves as a macropolyanion whose properties are modified by gegen ion association and in some instances by hemolysate adsorbed.
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TLDR
With the use of albumin-I131, the volume of plasma trapped in the packed cell column of hematocrit tubes was determined for blood samples obtained from 5 animal species and the reduction was most pronounced for goat blood.
Physiology and Biophysics of the Circulation
The polycarbonate sieves used in these experiments were manufactured for us by General Electric Atomic Products Division, Vallecitos Atomic Laboratories
  • Science
  • 1965
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