Blood Transfusions and Prognosis in Colorectal Cancer: Long-Term Results of a Randomized Controlled Trial

  title={Blood Transfusions and Prognosis in Colorectal Cancer: Long-Term Results of a Randomized Controlled Trial},
  author={J J Harlaar and Martijn P. Gosselink and Wim C. J. Hop and Johan F. Lange and Olivier R. C. Busch and Hans J Jeekel},
  journal={Annals of Surgery},
Objective:Perioperative blood transfusions may adversely affect survival in patients with colorectal malignancy, although definite proof of a causal relationship has never been reported. Background:We report the long-term outcomes of a randomized controlled trial performed between 1986 and 1991 to compare the effects of allogeneic blood transfusions and an autologous blood transfusion program in colorectal cancer patients. Methods:All 475 randomized patients operated upon for colorectal cancer… 

Perioperative transfusion and the prognosis of colorectal cancer surgery: a systematic review and meta-analysis

Perioperative transfusion causes a dramatically negative effect on long-term prognosis and increases short-term complications after colorectal cancer surgery.

Trial of intraoperative cell salvage versus transfusion in ovarian cancer (TIC TOC): protocol for a randomised controlled feasibility study

This is the protocol for a feasibility randomised controlled trial with an embedded qualitative study and feasibility economic evaluation to test the effectiveness and cost-effectiveness of ICS reinfusion versus donor blood transfusion in ovarian cancer surgery.

Restrictive allogeneic blood transfusion strategy in patients with extremity bone sarcomas

A restrictive ABT strategy may be safely performed in patients with extremity bone sarcomas depending on the intraoperative status and specific characteristics of each patient, as investigated in patients who underwent operations for extremityBone Sarcomas between May 2008 and November 2018.

A Meta-Analysis and Systematic Review of Perioperative Outcomes of Laparoscopic-assisted Rectal Resection (LARR) Versus Open Rectal Resection (ORR) for Carcinoma

LARR seems to be a safe and effective alternative to ORR; however, it needs to be performed in established colorectal units with experienced laparoscopic surgeons.

Comparison between autologous and homologous blood transfusions in liver resection for biliary tract cancer: a propensity score matching analysis

Surgical outcomes between patients receiving autologous and homologous transfusions during liver resection for biliary tract cancer (BTC) are compared.

Patient blood management in colorectal cancer patients: a survey among Dutch gastroenterologists, surgeons, and anesthesiologists

Assessment of the current PBM strategies in the Netherlands to assess the impact of preoperative anemia, associated with increased morbidity, is highly prevalent in colorectal cancer patients.

Assessment of Long-term Follow-up of Randomized Trial Participants by Linkage to Routinely Collected Data

The fate of patients after participation in clinical trials is a neglected topic, and the authors recommend that researchers routinely request permission from trial participants to study long-term treatment effects using linkage to routinely collected data.



The Association of Perioperative Blood Transfusion With Colorectal Cancer Recurrence

Using Cox proportional hazards model, the association of transfusion with disease-free survival was significant and peri-operative blood transfusion is a significant independent prognostic factor for colorectal cancer.

Perioperative blood transfusions for the recurrence of colorectal cancer.

All analyses support the hypothesis that PBT have a detrimental effect on the recurrence of curable colorectal cancers, although heterogeneity was detected.

Blood transfusion-modulated tumor recurrence: first results of a randomized study of autologous versus allogeneic blood transfusion in colorectal cancer surgery.

  • M. HeissW. Mempel F. Schildberg
  • Medicine, Biology
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 1994
The blood transfusion modality has a significant effect on tumor recurrence after surgical treatment of colorectal cancer and might thus potentially surpass the impact of any recent adjuvant treatment strategies.

Anaemia prior to operation is related with poorer long-term survival in patients with operable rectal cancer.

Pre and peri-operative erythropoietin for reducing allogeneic blood transfusions in colorectal cancer surgery.

There is no sufficient evidence to date to recommend pre and peri-operative erythropoietin use in colorectal cancer surgery, and there is no evidence for clinically significant changes.

An evaluation of the preoperative hemoglobin level as a prognostic factor for oral squamous cell carcinoma

Data suggests that an Hb of below 11 g/dl contributes to and is an indicator for a poor prognosis, and pre-treatment Hb corrections may significantly improve outcome, but further investigations, including blood transfusion/application of erythropoietin due to tumor anemia, independent of intraoperative blood-loss are necessary.

Anemia in cervical cancers: impact on survival, patterns of relapse, and association with hypoxia and angiogenesis.


The hypothesis that autologous blood transfusion does not contain immunologically neutral effects of allogeneic blood, but itself exerts an immunomodulatory effect is supported.