Blood Transcriptional Profiling Reveals Immunological Signatures of Distinct States of Infection of Humans with Leishmania infantum

@inproceedings{Gardinassi2016BloodTP,
  title={Blood Transcriptional Profiling Reveals Immunological Signatures of Distinct States of Infection of Humans with Leishmania infantum},
  author={Luiz Gardinassi and Gustavo R. Garc{\'i}a and Carlos Costa and Vladimir Costa Silva and Isabel Kinney Ferreira de Miranda Santos},
  booktitle={PLoS neglected tropical diseases},
  year={2016}
}
Visceral leishmaniasis (VL) can be lethal if untreated; however, the majority of human infections with the etiological agents are asymptomatic. Using Illumina Bead Chip microarray technology, we investigated the patterns of gene expression in blood of active VL patients, asymptomatic infected individuals, patients under remission of VL and controls. Computational analyses based on differential gene expression, gene set enrichment, weighted gene co-expression networks and cell deconvolution… CONTINUE READING

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