Blood T-cell receptor beta chain transcriptome in multiple sclerosis. Characterization of the T cells with altered CDR3 length distribution.

@article{Laplaud2004BloodTR,
  title={Blood T-cell receptor beta chain transcriptome in multiple sclerosis. Characterization of the T cells with altered CDR3 length distribution.},
  author={David-Axel Laplaud and Catherine E Ruiz and Sandrine Wiertlewski and Sophie Brouard and Laureline Berthelot and M Constant - Desportes G Guillet and Beno{\^i}t Melchior and Nicolas Degauque and Gilles Edan and Philippe Brachet and Philippe Damier and Jean Paul Soulillou},
  journal={Brain : a journal of neurology},
  year={2004},
  volume={127 Pt 5},
  pages={981-95}
}
Multiple sclerosis is an inflammatory demyelinating disease of the CNS associated with T cells autoreactive for myelin components. In this study, we analysed the T-cell receptor (TCR) usage of the variable beta (Vbeta) chain transcriptome in the blood of multiple sclerosis patients at various stages of the disease using a global and quantitative comparison of the complementarity-determining region 3 length distribution (CDR3-LD) of transcripts of the 26 Vbeta genes. We investigated 35 patients… CONTINUE READING