Blood Pressure and Renal Sodium Handling in Relation to Genetic Variation in the DRD 1 Promoter and GRK 4

@inproceedings{Staessen2008BloodPA,
  title={Blood Pressure and Renal Sodium Handling in Relation to Genetic Variation in the DRD 1 Promoter and GRK 4},
  author={Jan A Staessen and Tatiana Kuznetsova and Haifeng Zhang and Marc Maillard and Murielle Bochud and Sandra Hasenkamp and Judith Westerkamp and Tom Richart and Lutgarde Thijs and Xinli Li and Stefan-Martin Brand-Herrmann and Michel Burnier and E. T. Brand},
  year={2008}
}
Activation of type-1 dopamine receptors (DRD1) reduces renal sodium reabsorption. In a family-based random sample of 611 untreated whites (women, 45.0%; mean age, 38.6 years), we measured blood pressure (BP). We used the endogenous lithium clearance to assess fractional sodium excretion (FENa) and proximal (RNaprox) and distal (RNadist) tubular sodium reabsorption. We investigated multivariate-adjusted associations with the DRD1 promoter (A 48G, G 94A, and C 800T) and GRK4 (Ala142Val). The… CONTINUE READING

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