Blood Pressure Reduction and Secondary Stroke Prevention: A Systematic Review and Metaregression Analysis of Randomized Clinical Trials

  title={Blood Pressure Reduction and Secondary Stroke Prevention: A Systematic Review and Metaregression Analysis of Randomized Clinical Trials},
  author={Aristeidis H. Katsanos and Angeliki G. Filippatou and Efstathios Manios and Spyridon Deftereos and John Parissis and Alexandra Frogoudaki and Agathi Rosa Vrettou and Ignatios Ikonomidis and Maria Pikilidou and Odysseas Kargiotis and Konstantinos Voumvourakis and Anne W. Alexandrov and Andrei V. Alexandrov and Georgios Tsivgoulis},
Current recommendations do not specifically address the optimal blood pressure (BP) reduction for secondary stroke prevention in patients with previous cerebrovascular events. We conducted a systematic review and metaregression analysis on the association of BP reduction with recurrent stroke and cardiovascular events using data from randomized controlled clinical trials of secondary stroke prevention. For all reported events during each eligible study period, we calculated the corresponding… 

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