Blood Occludin Level as a Potential Biomarker for Early Blood Brain Barrier Damage Following Ischemic Stroke

@inproceedings{Pan2017BloodOL,
  title={Blood Occludin Level as a Potential Biomarker for Early Blood Brain Barrier Damage Following Ischemic Stroke},
  author={Rong Pan and Kewei Yu and Theodore Weatherwax and Handong Zheng and Wenlan Liu and Ke Jian Liu},
  booktitle={Scientific reports},
  year={2017}
}
Concern about intracerebral hemorrhage (ICH) is the primary reason for withholding tPA therapy from patients with ischemic stroke. Early blood brain barrier (BBB) damage is the major risk factor for fatal post-thrombolysis ICH, but rapidly assessing BBB damage before tPA administration is highly challenging. We recently reported that ischemia induced rapid degradation of tight junction protein occludin in cerebromicrovessels. The present study investigates whether the cleaved occludin is… CONTINUE READING
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MicroRNA-130a regulates cerebral ischemia-induced blood-brain barrier permeability by targeting Homeobox A5.

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The authors declare no competing financial interests

Liu, S. et al. Interstitial pO2 in ischemic penumbra, +13 authors edited the article. Additional Information Competing fina interests
  • How to cite this article: Pan, R. et al. Blood Occludin Level as a Potential Biomarker for Early Blood Brain Barrier Damage Following Ischemic Stroke. Sci. Rep. 7, 40331; doi: 10.1038/srep40331
  • 2017

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