Blood Occludin Level as a Potential Biomarker for Early Blood Brain Barrier Damage Following Ischemic Stroke

@article{Pan2017BloodOL,
  title={Blood Occludin Level as a Potential Biomarker for Early Blood Brain Barrier Damage Following Ischemic Stroke},
  author={R. Pan and K. Yu and Theodore Weatherwax and Handong Zheng and Wenlan Liu and K. Liu},
  journal={Scientific Reports},
  year={2017},
  volume={7}
}
  • R. Pan, K. Yu, +3 authors K. Liu
  • Published 2017
  • Medicine
  • Scientific Reports
  • Concern about intracerebral hemorrhage (ICH) is the primary reason for withholding tPA therapy from patients with ischemic stroke. Early blood brain barrier (BBB) damage is the major risk factor for fatal post-thrombolysis ICH, but rapidly assessing BBB damage before tPA administration is highly challenging. We recently reported that ischemia induced rapid degradation of tight junction protein occludin in cerebromicrovessels. The present study investigates whether the cleaved occludin is… CONTINUE READING
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    References

    SHOWING 1-10 OF 43 REFERENCES
    Oxygen Therapy Reduces Secondary Hemorrhage after Thrombolysis in Thromboembolic Cerebral Ischemia
    • Li Sun, W. Zhou, +5 authors R. Veltkamp
    • Medicine
    • Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
    • 2010
    • 62