Blood Monocyte-Derived Neohepatocytes as in Vitro Test System for Drug Metabolism

  title={Blood Monocyte-Derived Neohepatocytes as in Vitro Test System for Drug Metabolism},
  author={Sabrina Ehnert and Andreas K. Nussler and A. Lehmann and Steven Dooley},
  journal={Drug Metabolism and Disposition},
  pages={1922 - 1929}
The gold standard for human drug metabolism studies is primary hepatocytes. However, availability is limited by donor organ scarcity. Therefore, efforts have been made to provide alternatives, e.g., the hepatocyte-like (NeoHep) cell type, which was generated from peripheral blood monocytes. In this study, expression and activity of phase I and phase II drug-metabolizing enzymes were investigated during transdifferentiation of NeoHep cells and compared with primary human hepatocytes. Important… 

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