Blood Mitochondrial DNA Copy Number: What Are We Counting?

@article{Picard2021BloodMD,
  title={Blood Mitochondrial DNA Copy Number: What Are We Counting?},
  author={Martin Picard},
  journal={Mitochondrion},
  year={2021}
}
  • M. Picard
  • Published 19 June 2021
  • Medicine
  • Mitochondrion
There is growing scientific interest to develop scalable biological measures that capture mitochondrial (dys)function. Mitochondria have their own genome, the mitochondrial DNA (mtDNA), and it has been proposed that the number of mtDNA copies per cell (mtDNA copy number; mtDNAcn) reflects mitochondrial health. The common availability of stored DNA material or existing DNA sequencing data, especially from blood and other easy-to-collect samples, has made its quantification a popular approach in… Expand

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