Blood-Matching Goes Genetic

@article{Quill2008BloodMatchingGG,
  title={Blood-Matching Goes Genetic},
  author={Elizabeth A. Quill},
  journal={Science},
  year={2008},
  volume={319},
  pages={1478 - 1479}
}
Hoping to prevent adverse transfusion reactions and save lives, European researchers are lobbying to replace serology-based blood typing with matching based on DNA tests. 

Technologies involved in molecular blood group genotyping

TLDR
The haemagglutination test provides only indirect indications of risk or severity of haemolytic disease of the new born and nucleic acid‐based technologies have been used in immunohematology reference laboratories.

Development of a Blood Antigen Molecular Profiling Panel using Genotyping Technologies for Patients Requiring Frequent Transfusions

TLDR
Molecular profiling of blood donors for minor red blood cell and platelet antigens will give blood banks instant access to many different compatible donors through the set-up of a centralized data storage system.

Overcoming methodical limits of standard RHD genotyping by next‐generation sequencing

TLDR
This pilot study compared a newly established next‐generation sequencing approach based on pyrosequencing to determine rare and unknown RHD genotypes by sequence‐based typing by standard Sanger sequencing.

Molecular genotyping in transfusion medicine.

TLDR
SNPs account for much of human genome diversity, and the ability to link SNPs to disease or disease risk, and even to individual variation in drug responses, makes SNP profiling a technology likely to contribute to fulfilling the promise of personalized medicine.

Development of Cryopreserved Red Blood Cell Panels as Biological Reference Standards for Performance Evaluation of ABO and D Blood Grouping Reagents

TLDR
Developing Cryopreserved Red Blood Cell Panels as Biological Reference Standards for Performance Evaluation of ABO and D Blood Grouping Reagents for safe and effective transfusion.

Genotyping for human platelet alloantigen polymorphisms: applications in the diagnosis of alloimmune platelet disorders.

  • B. Curtis
  • Biology, Medicine
    Seminars in thrombosis and hemostasis
  • 2008
TLDR
Platelet genotyping is a valuable tool in confirming platelet antigen specificities of alloantibodies detected in patient sera to complement the clinical history in the diagnosis ofalloimmune platelet disorders such as fetal and neonatal alloimmune thrombocytopenia (FNAIT), posttransfusion purpura, and multiplatelet transfusion refractoriness.

Molecular Diagnostics in Transfusion Medicine: In Capillary, on a Chip, in Silico, or in Flight?

TLDR
The special focus of this paper is a relative new technique: SNP genotyping by MALDI-TOF MS analysis, which has the potential for automation, high throughput and cost effectiveness.

Blood group genotyping: from patient to high‐throughput donor screening

TLDR
Genotyping of blood donors will be extremely useful to obtain donor blood with rare phenotypes, for example lacking a high‐frequency antigen, and to obtain a fully typed donor database to be used for a better matching between recipient and donor to prevent adverse transfusion reactions.

Elucidating Genetic and Biochemical Aspects of the P1 and Sda Carbohydrate Histo-Blood Group Antigens

TLDR
The aim of this work was to elucidate the molecular genetic mechanisms behind the P1 and Sda antigens, as well as to study their glycan structures, and to define the genetic background of the Sd(a–) phenotype.