Blood HbO2 and HbCO2 Dissociation Curves at Varied O2, CO2, pH, 2,3-DPG and Temperature Levels

@article{Dash2004BloodHA,
  title={Blood HbO2 and HbCO2 Dissociation Curves at Varied O2, CO2, pH, 2,3-DPG and Temperature Levels},
  author={Ranjan K. Dash and James B. Bassingthwaighte},
  journal={Annals of Biomedical Engineering},
  year={2004},
  volume={32},
  pages={1676-1693}
}
New mathematical model equations for O2 and CO2 saturations of hemoglobin (S HbO 2 and S HbCO 2) are developed here from the equilibrium binding of O2 and CO2 with hemoglobin inside RBCs. They are in the form of an invertible Hill-type equation with the apparent Hill coefficients K HbO 2 and K HbCO 2 in the expressions for S HbO 2 and S HbCO 2 dependent on the levels of O2 and CO2 partial pressures (P O 2 and P CO 2), pH, 2,3-DPG concentration, and temperature in blood. The invertibility of… CONTINUE READING

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