Blood Glutamate Scavenging: Insight into Neuroprotection

@inproceedings{Leibowitz2012BloodGS,
  title={Blood Glutamate Scavenging: Insight into Neuroprotection},
  author={Akiva Leibowitz and Matthew Boyko and Yoram Shapira and Alexander A. Zlotnik},
  booktitle={International journal of molecular sciences},
  year={2012}
}
Brain insults are characterized by a multitude of complex processes, of which glutamate release plays a major role. Deleterious excess of glutamate in the brain's extracellular fluids stimulates glutamate receptors, which in turn lead to cell swelling, apoptosis, and neuronal death. These exacerbate neurological outcome. Approaches aimed at antagonizing the astrocytic and glial glutamate receptors have failed to demonstrate clinical benefit. Alternatively, eliminating excess glutamate from… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 177 REFERENCES

The blood-brain barrier and glutamate.

  • The American journal of clinical nutrition
  • 2009
VIEW 10 EXCERPTS
HIGHLY INFLUENTIAL

Effect of protein intake on plasma and erythrocyte free amino acids and serum IGF-I and IGFBP-1 levels in rats.

  • American journal of physiology. Endocrinology and metabolism
  • 1999
VIEW 13 EXCERPTS
HIGHLY INFLUENTIAL