Blood Glucose Levels Regulate Pancreatic β-Cell Proliferation during Experimentally-Induced and Spontaneous Autoimmune Diabetes in Mice

@article{Pechhold2009BloodGL,
  title={Blood Glucose Levels Regulate Pancreatic β-Cell Proliferation during Experimentally-Induced and Spontaneous Autoimmune Diabetes in Mice},
  author={Klaus Pechhold and Kerstin Koczwara and Xiaolong Zhu and Victor Sanoe Harrison and Greg Walker and Janet S. Lee and David M Harlan},
  journal={PLoS ONE},
  year={2009},
  volume={4},
  pages={758 - 768}
}
BACKGROUND Type 1 diabetes mellitus is caused by immune-mediated destruction of pancreatic beta-cells leading to insulin deficiency, impaired intermediary metabolism, and elevated blood glucose concentrations. While at autoimmune diabetes onset a limited number of beta-cells persist, the cells' regenerative potential and its regulation have remained largely unexplored. Using two mouse autoimmune diabetes models, this study examined the proliferation of pancreatic islet ss-cells and other… CONTINUE READING
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