Blood-Brain Barrier Permeability Is Regulated by Lipid Transport-Dependent Suppression of Caveolae-Mediated Transcytosis

@article{Andreone2017BloodBrainBP,
  title={Blood-Brain Barrier Permeability Is Regulated by Lipid Transport-Dependent Suppression of Caveolae-Mediated Transcytosis},
  author={Benjamin J. Andreone and Brian Wai Chow and Aleksandra Tata and Baptiste Lacoste and Ayal Ben-Zvi and Kevin H Bullock and Amy A. Deik and David D Ginty and Clary B Clish and Chenghua Gu},
  journal={Neuron},
  year={2017},
  volume={94},
  pages={581-594.e5}
}
The blood-brain barrier (BBB) provides a constant homeostatic brain environment that is essential for proper neural function. An unusually low rate of vesicular transport (transcytosis) has been identified as one of the two unique properties of CNS endothelial cells, relative to peripheral endothelial cells, that maintain the restrictive quality of the BBB. However, it is not known how this low rate of transcytosis is achieved. Here we provide a mechanism whereby the regulation of CNS… CONTINUE READING
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