Blood-Borne Activity-Dependent Neuroprotective Protein (ADNP) is Correlated with Premorbid Intelligence, Clinical Stage, and Alzheimer's Disease Biomarkers.

@article{Malishkevich2015BloodBorneAN,
  title={Blood-Borne Activity-Dependent Neuroprotective Protein (ADNP) is Correlated with Premorbid Intelligence, Clinical Stage, and Alzheimer's Disease Biomarkers.},
  author={Anna Malishkevich and Gad A Marshall and Aaron P. Schultz and Reisa A. Sperling and J. Aharon-Peretz and Illana Gozes},
  journal={Journal of Alzheimer's disease : JAD},
  year={2015},
  volume={50 1},
  pages={
          249-60
        }
}
Biomarkers for Alzheimer's disease (AD) are vital for disease detection in the clinical setting. Discovered in our laboratory, activity-dependent neuroprotective protein (ADNP) is essential for brain formation and linked to cognitive functions. Here, we revealed that blood borne expression of ADNP and its paralog ADNP2 is correlated with premorbid intelligence, AD pathology, and clinical stage. Age adjustment showed significant associations between: 1) higher premorbid intelligence and greater… CONTINUE READING

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