Blood-Based Microcirculation Markers in Alzheimer's Disease–Diagnostic Value of Midregional Pro-atrial Natriuretic Peptide/C-terminal Endothelin-1 Precursor Fragment Ratio

@article{Buerger2009BloodBasedMM,
  title={Blood-Based Microcirculation Markers in Alzheimer's Disease–Diagnostic Value of Midregional Pro-atrial Natriuretic Peptide/C-terminal Endothelin-1 Precursor Fragment Ratio},
  author={K. Buerger and Andrea Ernst and Michael Ewers and O. D. Uspenskaya and Muamer Omerovic and Nils G. Morgenthaler and Katharina Knauer and Andreas Bergmann and Harald Hampel},
  journal={Biological Psychiatry},
  year={2009},
  volume={65},
  pages={979-984}
}
BACKGROUND There is evidence that vascular factors contribute substantially to Alzheimer's disease (AD). We have developed assays to reliably detect the circulation and microcirculation regulating factors C-terminal endothelin-1 precursor fragment (CT-proET-1), midregional pro-adrenomedullin (MR-proADM), and midregional pro-atrial natriuretic peptide (MR-proANP). We hypothesized that this set of blood-based (micro)circulation parameters is altered in AD. METHODS Prospectively recruited… CONTINUE READING

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