Blood‐Oxygen Transport in First Trimester of Diabetic Pregnancy

  title={Blood‐Oxygen Transport in First Trimester of Diabetic Pregnancy},
  author={H. Madsen and J{\o}rn Ditzel},
  journal={Acta Obstetricia et Gynecologica Scandinavica},
  • H. Madsen, J. Ditzel
  • Published 1 January 1984
  • Medicine
  • Acta Obstetricia et Gynecologica Scandinavica
Abstract. Factors involved in blood‐oxygen transport were studied in 46 pregnant women during the first trimester. All had type 1 (insulin‐dependent) diabetes and comparisons were made with similar measurements from 19 non‐diabetic pregnant women, also in the first trimester. The concentration of hemoglobin 1c (HbA1c) was significantly increased (7.6% versus 4.4%, p <0.01) and arterial oxygen saturation was decreased (0.95 versus 0.98 mol/mol, p<0.01) in the pregnant diabetics compared with the… 
Fetal Acidosis and Hyperlacticaemia Diagnosed by Cordocentesis in Pregnancies Complicated by Maternal Diabetes Mellitus
It is suggested that some fetuses of diabetic women are significantly acidotic and hyperlacticaemic in the third trimester, which may provide a possible explanation for the phenomenon of late intrauterine fetal death in pregnancies complicated by maternal diabetes mellitus.
Exposure to maternal diabetes is associated with altered fetal growth patterns: A hypothesis regarding metabolic allocation to growth under hyperglycemic‐hypoxemic conditions
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The data suggest that the maternal–fetal interchange circuit, designed to share and capture resources on the fetal side, may not have had a long evolutionary history of overabundance as a selective force, and modern health problems drive postnatal sequelae that become exacerbated by increasing longevity.
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Gestational Diabetes
Pregnancy has been shown to have a diabetogenic effect on carbohydrate metabolism, increasing the glucose response to a mixed meal or a pure carbohydrate challenge, and it appears intuitive that the metabolic changes brought about by pregnancy might unmask incipient diabetes.
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Consequences of gestational and pregestational diabetes on placental function and birth weight.
Better research is needed to better understand the mechanisms that govern the early embryo development, the induction of congenital anomalies and fetal overgrowth in maternal diabetes.
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Peculiarities of placental microRNA expression in pregnancies complicated by gestational diabetes mellitus and preeclampsia
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Changes in red blood cell oxygen transport in diabetic pregnancy.
Hemoglobin A1c Determinations in Diabetic Pregnancy
HbA1c cannot satisfactorily describe the degree of diabetes control without simultaneous determinations of blood glucose, and is found to be a poor predictor of the average blood glucose concentration in the individual patient.
The results suggest that poor metabolic control of maternal diabetes during the second trimester is associated with a clearly increased risk of perinatal death and during the first and third trimesters with metabolic derangements in the neonatal period.
Oxygen affinity of whole blood in vivo and under standard conditions in subjects with diabetes mellitus.
Data interpreted in terms of the higher concentration of HbAIc in the blood of diabetic subjects indicate that this abnormality is compensated for by an increase in red cell DPG to give a normal oxygen affinity of the blood in vivo.
Changes in red cell oxygen release capacity in diabetes mellitus.
  • J. Ditzel
  • Medicine, Biology
    Federation proceedings
  • 1979
Studies are summarized to indicate that diabetes is associated with a fluctuating disturbance in the oxygen release capacity of the erythrocytes, and transient decreases in red cell oxygen delivery lead to dilatation of the venous part of the microcirculation associated with increased transcapillary plasma permeation.
Hemoglobin components in patients with diabetes mellitus.
The increase in proportions of glycohemoglobin in diabetes mellitus appears to be another example of increased glycoproteins in this disorder.
Congenital malformations: the possible role of diabetes care outside pregnancy.
It is indicated that poor diabetic control outside pregnancy is teratogenic, although the 'disastrous malformation factor' of diabetes appears not to be totally dependent on the degree of compensation of the disbetic metabolism, as measured by the variables usually applied.
Pregnancy and diabetes: a survey.
The findings suggest that poor diabetic control outside pregnancy might be teratogenic, and the importance of centralization of the management is emphasized.
The interaction of 2,3-diphosphoglycerate with various human hemoglobins.
Results suggest that the N-terminal amino groups of the non-alpha-chains are involved in the binding of 2,3-DPG to hemoglobin.
The Pregnant Diabetic and Her Newborn
In this 2nd edition J0rgen Pedersen has performed a service in lucid English and in a handy book for those paediatricians both old and new to this subject, the old may look critically at their own work through his discerning eyes and the young will find all the information they need before starting work on a problem which, like diabetes itself, is in some ways as challenging now as it was 25 years ago.