Blood‐Brain Barrier Abnormalities in Longstanding Multiple Sclerosis Lesions. An Immunohistochemical Study

  title={Blood‐Brain Barrier Abnormalities in Longstanding Multiple Sclerosis Lesions. An Immunohistochemical Study},
  author={Eunice E. Kwon and John W. Prineas},
  journal={Journal of Neuropathology and Experimental Neurology},
  • E. Kwon, J. Prineas
  • Published 1 November 1994
  • Biology, Medicine
  • Journal of Neuropathology and Experimental Neurology
Abstract. Thirty-five randomly selected plaques from five patients with longstanding multiple sclerosis were examined immunohistochemically for evidence of extravascular serum proteins. One lesion showed histological evidence of active demyelination and 34 were inactive. In the one active lesion and in 26 of the 34 inactive lesions, serum proteins were detected outside blood vessels in a distribution consistent with leakage during life. The findings suggest that the blood-brain barrier (BBS) is… 

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