Blocking very late antigen-4 integrin decreases leukocyte entry and fatty streak formation in mice fed an atherogenic diet.

@article{Shih1999BlockingVL,
  title={Blocking very late antigen-4 integrin decreases leukocyte entry and fatty streak formation in mice fed an atherogenic diet.},
  author={P T Shih and Marie Luise Brennan and Devendra K Vora and Mary C. Territo and Dr. S. Strahl and Mariano J. Elices and Aldons J. Lusis and Judith A. Berliner},
  journal={Circulation research},
  year={1999},
  volume={84 3},
  pages={345-51}
}
Atherosclerotic lesion development is characterized by the recruitment of leukocytes, principally monocytes, to the vessel wall. Considerable interest has been focused on the adhesion molecule(s) involved in leukocyte/endothelial interactions. The goal of the present study was to determine the role of the very late antigen-4 (VLA-4) integrin/ligand interaction in fatty streak development using murine models. Because alpha4 null mice are not viable, a peptidomimetic was used to block VLA-4… CONTINUE READING
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