Blocking transforming growth factor-β signaling pathway augments antitumor effect of adoptive NK-92 cell therapy.

@article{Yang2013BlockingTG,
  title={Blocking transforming growth factor-β signaling pathway augments antitumor effect of adoptive NK-92 cell therapy.},
  author={Bo Yang and Hui Liu and Weiwei Shi and Zhikuan Wang and Shenjie Sun and Guoqing Zhang and Yi Hu and Tianyi Liu and Shunchang Jiao},
  journal={International immunopharmacology},
  year={2013},
  volume={17 2},
  pages={198-204}
}
Natural killer (NK) cells hold great potential for improving the immunotherapy of cancer. However, existing data indicate that tumor cells can effectively escape NK cell-mediated apoptosis through immunosuppressive effect in the tumor microenvironment. Transforming growth factor-β (TGF-β) is a potent immunosuppressant. The present study was intended to develop a treatment strategy through adoptive transfer of TGF-β insensitive NK-92 cells. To block TGF-β signaling pathway, NK-92 cells were… CONTINUE READING