Blocking toll-like receptor 2 and 4 signaling during a stressor prevents stress-induced priming of neuroinflammatory responses to a subsequent immune challenge.

@article{Weber2013BlockingTR,
  title={Blocking toll-like receptor 2 and 4 signaling during a stressor prevents stress-induced priming of neuroinflammatory responses to a subsequent immune challenge.},
  author={Michael D Weber and Matthew G Frank and Julia L Sobesky and Linda R. Watkins and Steven F. Maier},
  journal={Brain, behavior, and immunity},
  year={2013},
  volume={32},
  pages={112-21}
}
Acute and chronic stressors sensitize or prime the neuroinflammatory response to a subsequent peripheral or central immunologic challenge. However, the neuroimmune process(es) by which stressors prime or sensitize subsequent neuroinflammatory responses remains unclear. Prior evidence suggested that toll-like receptors (TLRs) might be involved in the mediation of primed neuroinflammatory responses, but the role of TLRs during a stressor has never been directly tested. Here, a novel TLR2 and TLR4… CONTINUE READING

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