Blocking the protease-activated receptor 1-4 heterodimer in platelet-mediated thrombosis.

@article{Leger2006BlockingTP,
  title={Blocking the protease-activated receptor 1-4 heterodimer in platelet-mediated thrombosis.},
  author={Andrew J. Leger and Suzanne L Jacques and Jehangir Badar and Nicole C. Kaneider and Claudia K. Derian and Patricia Andrade-Gordon and Lidija Covic and Athan Kuliopulos},
  journal={Circulation},
  year={2006},
  volume={113 9},
  pages={1244-54}
}
BACKGROUND Thrombin is the most potent agonist of platelets and plays a critical role in the development of arterial thrombosis. Human platelets express dual thrombin receptors, protease-activated receptor (PAR) 1 and PAR4; however, there are no therapeutic strategies that effectively target both receptors. METHODS AND RESULTS Platelet aggregation studies demonstrated that PAR4 activity is markedly enhanced by thrombin-PAR1 interactions. A combination of bivalirudin (hirulog) plus a novel… CONTINUE READING
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