Blocking the mitochondrial apoptotic pathway preserves motor neuron viability and function in a mouse model of amyotrophic lateral sclerosis.

@article{Reyes2010BlockingTM,
  title={Blocking the mitochondrial apoptotic pathway preserves motor neuron viability and function in a mouse model of amyotrophic lateral sclerosis.},
  author={Nichole A. Reyes and Jill K. Fisher and Kathryn Austgen and Scott VandenBerg and Eric H. Huang and Scott A. Oakes},
  journal={The Journal of clinical investigation},
  year={2010},
  volume={120 10},
  pages={3673-9}
}
Apoptosis of motor neurons is a well-documented feature in amyotrophic lateral sclerosis (ALS) and related motor neuron diseases (MNDs). However, the role of apoptosis in the pathogenesis of these diseases remains unresolved. One possibility is that the affected motor neurons only succumb to apoptosis once they have exhausted functional capacity. If true, blocking apoptosis should confer no therapeutic benefit. To directly investigate this idea, we tested whether tissue-specific deletion in the… CONTINUE READING

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