Blocking the endogenous formation of N-nitroso compounds and related carcinogens.

@article{Bartsch1996BlockingTE,
  title={Blocking the endogenous formation of N-nitroso compounds and related carcinogens.},
  author={Helmut Bartsch and Norbert Frank},
  journal={IARC scientific publications},
  year={1996},
  volume={139},
  pages={
          189-201
        }
}
Humans are exposed to a wide range of nitrogen-containing compounds and nitrosating agents, such as nitrite, nitrate and nitrogen oxides (NOx), that can react in vivo to form potentially carcinogenic N-nitroso compounds (NOCs), as well as several carcinogenic C-nitro(so) or reactive diazo compounds. Nitrosating agents can also be synthesized endogenously by bacteria and activated macrophages via the nitric oxide (NO) synthase pathway. Endogenous nitrosation can thus occur at many locations in… CONTINUE READING

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