Blocking the bFGF/STAT3 interaction through specific signaling pathways induces apoptosis in glioblastoma cells

Abstract

We have reported that basic fibroblast growth factor (bFGF) demonstrates an intimate connection with signal transducer and activator of transcription 3 (STAT3) in malignant brain tumor cells. However, its mechanisms are still unclear. In this study, we used inhibitors to block specific signaling pathways, including JAK, PI3K/Akt, and Src pathways, to… (More)
DOI: 10.1007/s11060-014-1529-8

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