Blocking the VISTA pathway enhances disease progression in (NZB × NZW) F1 female mice

Abstract

V-domain Ig suppressor of T-cell activation (VISTA) is a critical negative checkpoint molecule involved in regulating the immune response. Targeting the pathway with an antagonist anti-VISTA antibody designated 13F3 has been shown to enhance disease severity in experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis. To… (More)
DOI: 10.1177/0961203317716322

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