Blocking sp1 transcription factor broadly inhibits extracellular matrix gene expression in vitro and in vivo: implications for the treatment of tissue fibrosis.

@article{Verrecchia2001BlockingST,
  title={Blocking sp1 transcription factor broadly inhibits extracellular matrix gene expression in vitro and in vivo: implications for the treatment of tissue fibrosis.},
  author={Franck Verrecchia and J{\'e}r{\^o}me Rossert and Alain Mauviel},
  journal={The Journal of investigative dermatology},
  year={2001},
  volume={116 5},
  pages={755-63}
}
Fibrosis is a consequence of injury characterized by accumulation of excess collagen and other extracellular matrix components, resulting in the destruction of normal tissue architecture and loss of function. Sp1 was originally described as a ubiquitous transcription factor. It is involved in the basal expression of extracellular matrix genes and may, therefore, be important in fibrotic processes. To evaluate the effect of Sp1 blockade on the expression of extracellular matrix genes, clones of… CONTINUE READING

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