Blocking protein geranylgeranylation is essential for lovastatin-induced apoptosis of human acute myeloid leukemia cells

@article{Xia2001BlockingPG,
  title={Blocking protein geranylgeranylation is essential for lovastatin-induced apoptosis of human acute myeloid leukemia cells},
  author={Zuping Xia and M M Tan and Wendy Wei-Lynn Wong and Jim Dimitroulakos and M D Minden and L Z Penn},
  journal={Leukemia},
  year={2001},
  volume={15},
  pages={1398-1407}
}
Lovastatin is an inhibitor of the enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, the major regulatory enzyme of the mevalonate pathway. We have previously reported that lovastatin induces a significant apoptotic response in human acute myeloid leukemia (AML) cells. To identify the critical biochemical mechanism(s) essential for lovastatin-induced apoptosis, add-back experiments were conducted to determine which downstream product(s) of the mevalonate pathway could suppress… CONTINUE READING

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