Blocking of the amino groups of histone proteins by glucose

Abstract

We have reported previously that if sections of ethanol-fixed rat organs are extracted with trichloroacetic acid (TCA) and then incubated with glucose 6phosphate for 12 h, the DNA-negative cell nuclei still stain with basic dyes (Jobst et al., 1989). We suggested that this is due to the condensation of the lysine eamino groups of histones with the aldehyde… (More)
DOI: 10.1007/BF01047115

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