Blocking of acquisition but not expression of conditioned fear-potentiated startle by NMDA antagonists in the amygdala

@article{Miserendino1990BlockingOA,
  title={Blocking of acquisition but not expression of conditioned fear-potentiated startle by NMDA antagonists in the amygdala},
  author={Mindy J. D. Miserendino and Catherine B. Sananes and Kathleen R. Melia and Michael Davis},
  journal={Nature},
  year={1990},
  volume={345},
  pages={716-718}
}
RECEPTORS for N-methyl-D-aspartate (NMDA) seem to have a critical role in synaptic plasticity1–4. NMDA antagonists (such as AP5) prevent induction of long-term potentiation5,6, an activity-dependent enhancement of synaptic efficacy mediated by neural mechanisms that might also underlie learning and memory. They also attenuate memory formation in several behavioural tasks7–17; there are few data, however, implicating an NMDA-sensitive measure of conditioning based on local infusion of… CONTINUE READING
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