Blocking of Tat-dependent HIV-1 RNA modification by an inhibitor of RNA polymerase II processivity

@article{Braddock1991BlockingOT,
  title={Blocking of Tat-dependent HIV-1 RNA modification by an inhibitor of RNA polymerase II processivity},
  author={Martin Braddock and Andrew M. Thorburn and Alan J. Kingsman and Susan M. Kingsman},
  journal={Nature},
  year={1991},
  volume={350},
  pages={439-441}
}
HUMAN immunodeficiency virus gene expression is regulated transcriptionally and post-transcriptionally1–4 by the virally encoded tat protein (Tat). Tat functions through an RNA target sequence located in the untranslated region at the 5′ end of viral transcripts5–8. In Xenopus oocytes, translation of RNA containing the target sequence is specifically activated by Tat. This activation only occurs if the RNA is injected into the nucleus, and might be due to a Tat-dependent, nucleus-specific… CONTINUE READING

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