Blocking of SMAD4 expression by shRNA effectively inhibits fibrogenesis of human hepatic stellate cells

@inproceedings{Khanizadeh2015BlockingOS,
  title={Blocking of SMAD4 expression by shRNA effectively inhibits fibrogenesis of human hepatic stellate cells },
  author={Sayyad Khanizadeh and Mehrdad Ravanshad and SeyedYounes Hosseini and Parivash Davoodian and Azim Nejati Zadeh and Jamal Sarvari},
  booktitle={Gastroenterology and hepatology from bed to bench},
  year={2015}
}
AIM In this study, to clarify the SMAD4 blocking impact on fibrosis process, we investigated its down-regulation by shRNA on activated human LX-2 cell, in vitro. BACKGROUND Liver fibrosis is a critical consequence of chronic damage to the liver that can progress toward advanced diseases, liver cirrhosis and hepatocellular carcinoma (HCC). Different SMAD proteins play as major mediators in the fibrogenesis activity of hepatic stellate cells through TGF-β pathways, but the extent of SMAD4 as a… CONTINUE READING

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