Blocking of EGF-dependent cell proliferation by EGF receptor kinase inhibitors

@article{Yaish1988BlockingOE,
  title={Blocking of EGF-dependent cell proliferation by EGF receptor kinase inhibitors},
  author={Pnina Yaish and Aviv Gazit and Chaim Gilon and Alexander Levitzki},
  journal={Science},
  year={1988},
  volume={242},
  pages={933 - 935}
}
A systematic series of low molecular weight protein tyrosine kinase inhibitors were synthesized; they had progressively increasing affinity over a 2500-fold range toward the substrate site of epidermal growth factor (EGF) receptor kinase domain. These compounds inhibited EGF receptor kinase activity up to three orders of magnitude more than they inhibited insulin receptor kinase, and they also effectively inhibited the EGF-dependent autophosphorylation of the receptor. The most potent compounds… 
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