Blocking mu opioid receptors in the spinal cord prevents the analgesic action by subsequent systemic opioids.

@article{Chen2006BlockingMO,
  title={Blocking mu opioid receptors in the spinal cord prevents the analgesic action by subsequent systemic opioids.},
  author={Shao-rui Chen and H L Pan},
  journal={Brain research},
  year={2006},
  volume={1081 1},
  pages={119-25}
}
Systemically administered mu opioids may produce analgesia through inhibition of the ascending nociceptive transmission and activation of descending pathways. However, the relative importance of the spinal and supraspinal sites in the analgesic action of systemic opioids remains uncertain. It has been shown that systemic morphine can inhibit dorsal horn neurons independent of the descending system. In this study, we determined the extent to which spinal mu opioid receptors mediate the analgesic… CONTINUE READING

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