Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the Venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior.

@article{Gee2014BlockingMG,
  title={Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the Venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior.},
  author={Christine Elizabeth Gee and Daniel Peterlik and Christoph Neuhaeuser and Rochdi Bouhelal and Klemens Kaupmann and Grit Laue and Nicole Uschold-Schmidt and Dominik Feuerbach and Kaspar Zimmermann and Silvio Ofner and John F Cryan and Herman van der Putten and Markus Fendt and Ivo Vranesic and Ralf Glatthar and Peter Josef Flor},
  journal={The Journal of biological chemistry},
  year={2014},
  volume={289 16},
  pages={10975-87}
}
The metabotropic glutamate receptor subtype 7 (mGlu7) is an important presynaptic regulator of neurotransmission in the mammalian CNS. mGlu7 function has been linked to autism, drug abuse, anxiety, and depression. Despite this, it has been difficult to develop specific blockers of native mGlu7 signaling in relevant brain areas such as amygdala and limbic cortex. Here, we present the mGlu7-selective antagonist 7-hydroxy-3-(4-iodophenoxy)-4H-chromen-4-one (XAP044), which inhibits lateral amygdala… CONTINUE READING
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