Blocking macrophage leukotriene b4 prevents endothelial injury and reverses pulmonary hypertension.

  title={Blocking macrophage leukotriene b4 prevents endothelial injury and reverses pulmonary hypertension.},
  author={Wen Tian and Xinguo Jiang and Rasa Tamosiuniene and Yon K. Sung and Jin Qian and Gundeep Dhillon and Lajos Gera and Laszlo Farkas and Marlene Rabinovitch and Roham T. Zamanian and Mohammed Inayathullah and Marina Fridlib and Jayakumar Rajadas and Marc Peters-Golden and Norbert Felix Voelkel and Mark R Nicolls},
  journal={Science translational medicine},
  volume={5 200},
Pulmonary hypertension (PH) is a serious condition that affects mainly young and middle-aged women, and its etiology is poorly understood. A prominent pathological feature of PH is accumulation of macrophages near the arterioles of the lung. In both clinical tissue and the SU5416 (SU)/athymic rat model of severe PH, we found that the accumulated macrophages expressed high levels of leukotriene A4 hydrolase (LTA4H), the biosynthetic enzyme for leukotriene B4 (LTB4). Moreover, macrophage-derived… CONTINUE READING
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