Blocking histone deacetylation in Arabidopsis induces pleiotropic effects on plant gene regulation and development.

@article{Tian2001BlockingHD,
  title={Blocking histone deacetylation in Arabidopsis induces pleiotropic effects on plant gene regulation and development.},
  author={Lu Tian and Zhijian J Chen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98 1},
  pages={200-5}
}
Histone acetylation and deacetylation play essential roles in eukaryotic gene regulation. Reversible modifications of core histones are catalyzed by two intrinsic enzymes, histone acetyltransferase and histone deacetylase (HD). In general, histone deacetylation is related to transcriptional gene silencing, whereas acetylation correlates with gene activation. We produced transgenic plants expressing the antisense Arabidopsis HD (AtHD1) gene. AtHD1 is a homolog of human HD1 and RPD3 global… CONTINUE READING
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