Blocking effect of tripelennamine on histamine--induced positive chronotropic and inotropic responses of the dog atrium.

  • Sota Chiba
  • Published 1976 in The Tohoku journal of experimental medicine

Abstract

The effects of histamine on inotropic and chronotropic activity were investigated in isolated canine atrium preparations which were suspended in a bath and perfused with arterial blood from a carotid artery of heparinized support dog. Histamine administered into the cannulated sinus node artery in a dose range of 0.3-100 mug produced dose-related positive… (More)

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