Blocking effect of a biotinylated protease inhibitor on the egress of Plasmodium falciparum merozoites from infected red blood cells.

@article{Gelhaus2005BlockingEO,
  title={Blocking effect of a biotinylated protease inhibitor on the egress of Plasmodium falciparum merozoites from infected red blood cells.},
  author={Christoph Gelhaus and Radim Vic{\'i}k and Tanja Schirmeister and Matthias Leippe},
  journal={Biological chemistry},
  year={2005},
  volume={386 5},
  pages={499-502}
}
The malaria parasite Plasmodium falciparum invades human red blood cells. Before infecting new erythrocytes, the merozoites have to exit their host cell to get into the blood plasma. Knowledge about the mechanism of egress is scarce, but it is thought that proteases are basically involved in this step. We have introduced a biotinylated dibenzyl aziridine-2,3-dicarboxylate (bADA) as an irreversible cysteine protease inhibitor to study the mechanism of merozoite release and to identify the… CONTINUE READING

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