Blocking chloride channels in the rat lens: localized changes in tissue hydration support the existence of a circulating chloride flux.

@article{Young2000BlockingCC,
  title={Blocking chloride channels in the rat lens: localized changes in tissue hydration support the existence of a circulating chloride flux.},
  author={Miriam A Young and Mark J. Tunstall and Joerg Kistler and Paul James Donaldson},
  journal={Investigative ophthalmology & visual science},
  year={2000},
  volume={41 10},
  pages={3049-55}
}
PURPOSE To investigate the effects of inhibitors of chloride channels on lens volume and tissue architecture under isotonic conditions. METHODS Rat lenses were maintained in organ culture under isotonic conditions in the presence of various putative chloride channel inhibitors. The effect of an inhibitor on lens wet mass and tissue morphology was determined by weighing and histologic examination, respectively. RESULTS Exposure to 100 microM of either 5-nitro-2- (3-phenylpropylamino) benzoic… CONTINUE READING