Blocking cell microtubule assembly inhibits the alloimmune response in vitro and prolongs renal allograft survival by inhibition of Th1 and sparing of Th2 cell function in vivo.

@article{Akalin1995BlockingCM,
  title={Blocking cell microtubule assembly inhibits the alloimmune response in vitro and prolongs renal allograft survival by inhibition of Th1 and sparing of Th2 cell function in vivo.},
  author={Enver Akalin and Wayne W Hancock and Norberto Perico and Giuseppe Remuzzi and O Imberti and Charles B. Carpenter and Mohamed H. Sayegh},
  journal={Journal of the American Society of Nephrology : JASN},
  year={1995},
  volume={5 7},
  pages={1418-25}
}
Colchicine inhibits cell microtubule assembly by binding to and preventing the polymerization of tubulin monomers. Although there are data to indicate that colchicine inhibits a variety of cell-mediated immune responses, the effects and mechanisms of inhibiting cell microtubule assembly on the alloimmune response have not been thoroughly investigated. It has recently been shown that colchicine prevents acute rejection and promotes the long-term survival of rat renal allografts. In this study… CONTINUE READING