Blocking autophagy enhances the apoptosis effect of bufalin on human hepatocellular carcinoma cells through endoplasmic reticulum stress and JNK activation

@article{Hu2013BlockingAE,
  title={Blocking autophagy enhances the apoptosis effect of bufalin on human hepatocellular carcinoma cells through endoplasmic reticulum stress and JNK activation},
  author={Fengli Hu and Jiwu Han and Bo Zhai and Xiaodong Ming and Liwei Zhuang and Yong Liu and Shangha Pan and Tiefu Liu},
  journal={Apoptosis},
  year={2013},
  volume={19},
  pages={210-223}
}
Bufalin extracts are a part of traditional Chinese medicine, Chansu. In the current study, we investigated the effect of bufalin on the proliferation of the human hepatocellular carcinoma (HCC) cell lines, Huh-7 and HepG-2, and explored the therapeutic potential of the drug. Our results demonstrated that bufalin markedly inhibited cell proliferation and promoted apoptosis in the Huh-7 and HepG-2 cells in vitro. The underlying mechanism of the bufalin-induced apoptosis was the induction of… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 20 extracted citations

Autophagy and liver cancer.

The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology • 2018
View 1 Excerpt

Degradation of Mcl-1 through GSK-3β Activation Regulates Apoptosis Induced by Bufalin in Non-Small Cell Lung Cancer H1975 Cells.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology • 2017

References

Publications referenced by this paper.
Showing 1-10 of 56 references

IRE1: ER stress sensor and cell fate executor.

Trends in cell biology • 2013
View 11 Excerpts
Highly Influenced

From acute ER stress to physiological roles of the Unfolded Protein Response

Cell Death and Differentiation • 2006
View 11 Excerpts
Highly Influenced

Management of hepatocellular carcinoma

Journal of Cancer Research and Clinical Oncology • 2014
View 1 Excerpt

Similar Papers

Loading similar papers…