Blocking Tumor-Educated MSC Paracrine Activity Halts Osteosarcoma Progression.

  title={Blocking Tumor-Educated MSC Paracrine Activity Halts Osteosarcoma Progression.},
  author={Serena Rubina Bagl{\'i}o and Tonny Lagerweij and Maria P{\'e}rez-Lanz{\'o}n and Xuan Dung Ho and Nicolas L{\'e}veill{\'e} and S{\'o}nia A. Melo and Anne-Marie Cleton-Jansen and Ekaterina S Jordanova and Laura Roncuzzi and Michelina Greco and Monique A J van Eijndhoven and Giulia Grisendi and Massimo Dominici and Roberta Bonafede and Sin{\'e}ad M. Lougheed and Tanja D. de Gruijl and Nicoletta Zini and Silvia Cervo and Agostino Steffan and Vincenzo Canzonieri and Aare Martson and Katre Maasalu and Sulev K{\"o}ks and Tom Wurdinger and Nicola Baldini and D Michiel Pegtel},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={23 14},
Purpose: Human osteosarcoma is a genetically heterogeneous bone malignancy with poor prognosis despite the employment of aggressive chemotherapy regimens. Because druggable driver mutations have not been established, dissecting the interactions between osteosarcoma cells and supporting stroma may provide insights into novel therapeutic targets.Experimental Design: By using a bioluminescent orthotopic xenograft mouse model of osteosarcoma, we evaluated the effect of tumor extracellular vesicle… CONTINUE READING
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