Blocking TH17-polarizing cytokines by histone deacetylase inhibitors in vitro and in vivo.

@article{Bosisio2008BlockingTC,
  title={Blocking TH17-polarizing cytokines by histone deacetylase inhibitors in vitro and in vivo.},
  author={Daniela Bosisio and Marisa Vulcano and Annalisa Del Prete and Marina Sironi and Valentina Salvi and Laura Salogni and Elena Riboldi and Flavio Leoni and Charles A Dinarello and Giampiero Girolomoni and Silvano Sozzani},
  journal={Journal of leukocyte biology},
  year={2008},
  volume={84 6},
  pages={1540-8}
}
Histone deacetylase (HDAC) inhibitors are small molecules inducing cell-cycle arrest, differentiation, and apoptosis, currently undergoing clinical trials as anticancer drugs. In addition, emerging evidence suggests HDAC inhibitors may have anti-inflammatory and immunomodulatory properties as well, although the molecular mechanisms remain poorly defined. Given the central role of dendritic cells (DC) in the induction and maintenance of the inflammatory and immune response, we investigated the… CONTINUE READING

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