Blocking Synaptic Removal of GluA2-Containing AMPA Receptors Prevents the Natural Forgetting of Long-Term Memories.

@article{Migues2016BlockingSR,
  title={Blocking Synaptic Removal of GluA2-Containing AMPA Receptors Prevents the Natural Forgetting of Long-Term Memories.},
  author={Paola Virginia Migues and Lidong Liu and Georgina E B Archbold and Einar {\"O} Einarsson and Jacinda Wong and Kyra Bonasia and Seung Hyun Ko and Yu Tian Wang and Oliver Hardt},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2016},
  volume={36 12},
  pages={3481-94}
}
UNLABELLED The neurobiological processes underpinning the natural forgetting of long-term memories are poorly understood. Based on the critical role of GluA2-containing AMPA receptors (GluA2/AMPARs) in long-term memory persistence, we tested in rats whether their synaptic removal underpins time-dependent memory loss. We found that blocking GluA2/AMPAR removal with the interference peptides GluA23Y or G2CT in the dorsal hippocampus during a memory retention interval prevented the normal… CONTINUE READING
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Losing Connections, Losing Memory: AMPA Receptor Endocytosis as a Neurobiological Mechanism of Forgetting.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2016
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References

Publications referenced by this paper.
Showing 1-10 of 59 references

Essential role for a long-term depression mechanism in ocular dominance plasticity.

Proceedings of the National Academy of Sciences of the United States of America • 2009
View 15 Excerpts
Highly Influenced

Interaction of the AMPA receptor subunit GluR2/3 with PDZ domains regulates hippocampal long-term depression.

Proceedings of the National Academy of Sciences of the United States of America • 2001
View 7 Excerpts
Highly Influenced

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