Blocking PGE2-induced tumour repopulation abrogates bladder cancer chemoresistance

  title={Blocking PGE2-induced tumour repopulation abrogates bladder cancer chemoresistance},
  author={Antonina V. Kurtova and Jing Xiao and Qianxing Mo and Senthil Pazhanisamy and Ross E Krasnow and Seth P. Lerner and Fengju Chen and Terrence T. Roh and Erica Lay and Philip Levy Ho and Keith Syson Chan},
Cytotoxic chemotherapy is effective in debulking tumour masses initially; however, in some patients tumours become progressively unresponsive after multiple treatment cycles. Previous studies have demonstrated that cancer stem cells (CSCs) are selectively enriched after chemotherapy through enhanced survival. Here we reveal a new mechanism by which bladder CSCs actively contribute to therapeutic resistance via an unexpected proliferative response to repopulate residual tumours between… CONTINUE READING
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