Blocking NMDA receptors or nitric oxide production disrupts light transmission to the suprachiasmatic nucleus.

@article{Amir1992BlockingNR,
  title={Blocking NMDA receptors or nitric oxide production disrupts light transmission to the suprachiasmatic nucleus.},
  author={Shimon Amir},
  journal={Brain research},
  year={1992},
  volume={586 2},
  pages={336-9}
}
Retinal stimulation with a brief pulse of light (200 lx, 3 min) stimulated heart rate in dark-adapted urethane-anaesthetized rats. This effect was inhibited by prior infusion of a competitive blocker of N-methyl-D-aspartate (NMDA) receptors, (+-)-3-(2-carboxypiperazin-4-yl)-propyl-L-phosphonic acid (CPP, 20 nmol) into the hypothalamic suprachiasmatic nucleus (SCN) region. Furthermore, this inhibition of the stimulatory effect of light on heart rate was mimicked by prior infusion in the SCN… CONTINUE READING
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