Blocking NK cell inhibitory self-recognition promotes antibody-dependent cellular cytotoxicity in a model of anti-lymphoma therapy.

@article{Binyamin2008BlockingNC,
  title={Blocking NK cell inhibitory self-recognition promotes antibody-dependent cellular cytotoxicity in a model of anti-lymphoma therapy.},
  author={Liat Binyamin and R Katherine Alpaugh and Tracey Hughes and Charles T. Lutz and Kerry S Campbell and Louis M. Weiner},
  journal={Journal of immunology},
  year={2008},
  volume={180 9},
  pages={
          6392-401
        }
}
Human NK cells lyse Ab-coated target cells through the process of Ab-dependent cellular cytotoxicity (ADCC). Improving ADCC responses is desirable because it is thought to be an important antitumor mechanism for some Abs. NK cell inhibitory receptors, such as killer cell Ig-like receptors, engage with MHC class I molecules on self-cells to block NK cell activation. Accordingly, we enhanced ADCC responses by blocking NK cell inhibitory receptors, thus perturbing induction of the self-recognition… CONTINUE READING

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