Corpus ID: 28206750

Blocking NFk B Is Essential for the Immunotherapeutic Effect of Recombinant IL 18 in Pancreatic Cancer

@inproceedings{Guo2016BlockingNB,
  title={Blocking NFk B Is Essential for the Immunotherapeutic Effect of Recombinant IL 18 in Pancreatic Cancer},
  author={Xingjun Guo and Lei Zheng and Jianxin Jiang and Yan Zhao and Xin Wang and Ming Shen and F. Zhu and R. Tian and Cheng-jian Shi and Meng Xu and Xu Li and F. Peng and Hang Zhang and Yechen Feng and Yu Xie and Xiaodong Xu and W. Jia and Ruizhi He and Chenchen Xie and Jun X Hu and Dawei Ye and M. Wang and R. Qin},
  year={2016}
}
Purpose:We sought to find new immune-based treatments for pancreatic cancer. Experimental Design: We detected IL18 expression in plasma and specimens from patients with pancreatic cancer. We then investigated whether IL18 had a therapeutic effect for pancreatic cancer in vitro and in vivo and any underlying mechanisms. Results:Higher plasma IL18 was associated with longer overall survival (OS), but higher IL18 in pancreatic cancer tissues was associatedwith shorterOS and increased invasion… Expand

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References

SHOWING 1-10 OF 37 REFERENCES
IL-18 Inhibits Growth of Murine Orthotopic Prostate Carcinomas via Both Adaptive and Innate Immune Mechanisms
TLDR
It is suggested that local IL-18 in the tumor environment can significantly potentiate anti-tumor immunity in the prostate and clearly demonstrate that this effect is mediated by innate and adaptive immune mechanisms. Expand
Intratumoral delivery of IL-18 naked DNA induces T-cell activation and Th1 response in a mouse hepatic cancer model
TLDR
The results suggest that direct plasmid DNA transfer of IL-18 with no accompanying reagents to augment transfection efficiency may be useful in tumor immunotherapy. Expand
Immunotherapeutic approach for better management of cancer--role of IL-18.
TLDR
Roles of IL-18 in immune evasion, metastasis and angiogenesis, applications for chemotherapy and prognostic or diagnostic significance are covered, including combinational effects of cytokines with IL- 18 in cancer progression. Expand
NF-κB as a target for pancreatic cancer therapy
TLDR
Although the inhibition of NF-κB, especially when combined with more classic chemotherapeutic drugs, could be a promising therapeutic strategy, direct targeting NF-β still faces important challenges and targeting nonredundant cytosolic mediators of the activation of NF -κB could represent a better approach to inhibit key processes in pancreatic tumor cells. Expand
Dual effects of interleukin-18: inhibiting hepatitis B virus replication in HepG2.2.15 cells and promoting hepatoma cells metastasis.
  • Yijuan Zhang, Yunbo Li, +9 authors L. Ye
  • Biology, Medicine
  • American journal of physiology. Gastrointestinal and liver physiology
  • 2011
TLDR
The dual effects of IL-18 in human hepatocytes were revealed: it not only inhibited HBV replication but also promoted hepatoma cells metastasis and migration, and NF-κB played a critical role in both effects. Expand
IL-18 enhances the migration ability of murine melanoma cells through the generation of ROI and the MAPK pathway.
TLDR
IL-18 enhances the ability of melanoma cells to migrate via the generation of ROI and the MAPK pathway, and an antioxidant, N-acetyl-l-cystein (NAC), blocked the effect of IL-18 on migration. Expand
Interleukin (IL)‐18, a biomarker of human ovarian carcinoma, is predominantly released as biologically inactive precursor
TLDR
The data indicate that immunoreactive IL‐18 is increased in EOC patients' sera at diagnosis as compared with age‐matched healthy women, and that its lack of biological activity may represent a mechanism of tumor‐escape. Expand
Inhibition of NF-kappaB activity by BAY 11-7082 increases apoptosis in multidrug resistant leukemic T-cell lines.
Multidrug resistance (MDR) is the main reason for failure of cancer therapy with resistance to apoptosis being one of the mechanisms involved. Constitutive NF-kappaB activity has been detected inExpand
Interleukin-18 is a critical factor for vascular endothelial growth factor-enhanced migration in human gastric cancer cell lines
TLDR
Results suggest that rhVEGF-165 enhances IL-18 production via the generation of ROI and ERK1/2 phosphorylation, which results in the increased migration of gastric cancer cells. Expand
EGF-IL-18 fusion protein as a potential anti-tumor reagent by induction of immune response and apoptosis in cancer cells.
TLDR
EGF-IL-18 could induce significant tumor regression in SMMC-7721-xenografted Balb/c nude mice when administered together with peritumoral injection of X-ray-irradiated NK-92 cells, and this regression is associated with arresting of the tumor cells in G1 phase and induction of apoptosis. Expand
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