Corpus ID: 28206750

Blocking NFk B Is Essential for the Immunotherapeutic Effect of Recombinant IL 18 in Pancreatic Cancer

  title={Blocking NFk B Is Essential for the Immunotherapeutic Effect of Recombinant IL 18 in Pancreatic Cancer},
  author={Xingjun Guo and Lei Zheng and Jianxin Jiang and Yan Zhao and Xin Wang and Ming Shen and F. Zhu and R. Tian and Cheng-jian Shi and Meng Xu and Xu Li and F. Peng and Hang Zhang and Yechen Feng and Yu Xie and Xiaodong Xu and W. Jia and Ruizhi He and Chenchen Xie and Jun X Hu and Dawei Ye and M. Wang and R. Qin},
Purpose:We sought to find new immune-based treatments for pancreatic cancer. Experimental Design: We detected IL18 expression in plasma and specimens from patients with pancreatic cancer. We then investigated whether IL18 had a therapeutic effect for pancreatic cancer in vitro and in vivo and any underlying mechanisms. Results:Higher plasma IL18 was associated with longer overall survival (OS), but higher IL18 in pancreatic cancer tissues was associatedwith shorterOS and increased invasion… Expand

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